The anti-inflammatory and repairing abilities of our Perilla frutescens phytocomplex have been tested.

ReSILEMcare CROP®-G is the protagonist of the scientific publication “A Novel Perilla frutescens (L.) Britton Cell-Derived Phytocomplex Regulates Keratinocytes Inflammatory Cascade and Barrier Function and Preserves Vaginal Mucosal Integrity In Vivo“, published in the journal Pharmaceutics 15 (2023), a work born from the collaboration between Aethera Biotech, the University of Modena and Reggio Emilia, the University of Siena, the University of Florence and Eurochem Ricerche srl.

Through careful selection of the appropriate cell culture medium, it has been possible to obtain a line of P. frutescens, with a high content of rosmarinic acid and total polyphenols, resulting in a new ingredient with sustainability and safety characteristics guaranteed by the CROP® process.

The balance of the intimate area – closely correlated with the hormonal balance and general health of women – is nowadays subjected to factors such as pollution, endocrine disruptors, and stress. In the study, the efficacy of the P. frutescens phytocomplex in preserving the integrity of the vaginal mucosa in peri-menopausal women was tested.

In vitro test

The cell viability in an in-vitro model of vaginal mucosa after the application of an aqueous solution containing P. frutescens phytocomplex compared to an irritant solution, and a control sample was analysed. The results show that the use of the P. frutescens phytocomplex does not influence the cell viability of the mucosa in vitro, unlike the control sample.

The soothing capacity of Perilla frutescens phytocomplex was also analysed.  By using a phytocomplex solution compared to an acetylsalicylic acid solution (positive control) on a reconstituted mucosa in an irritated condition, the soothing ability of perilla could be tested and proven, which counteracted the irritation and increased cell viability by approximately 10%.

In vivo testing

The efficacy of the P.frutescens phytocomplex was tested in vivo with an intimate tissue mask in association with an intimate cream versus placebo, on female volunteers with problems of vaginal dryness, irritation, and loss of tone in pre/post menopause. Two weeks after use, treatment with the P. frutescens phytocomplex improved the total skin elasticity of the women tested, unlike those treated with a placebo.

The results obtained tested and proved the anti-inflammatory, protective, soothing, and moisturizing capacity of the phytocomplex derived from meristematic cells of P.frutescens – ReSILEMcare CROP®-G – as an innovative new ingredient for intimate health wellbeing.

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