ForsINgen CROP®-G

Rebalancing for a global purity effect

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personal care

ForsINgen CROP®-G is a highly concentrated standardized phytocomplex of meristematic cells of Forsythia suspensa titrated in total polyphenols expressed as verbascoside equivalent.

ForsINgen CROP®-G is a raw material verified by ECOCERT GREENLIFE, compliant with the COSMOS Standard.

claims suggestions

  • Deep balancing action: antioxidant and anti-inflammatory activities for scalp and skin
  • Sebo-regulation effect, especially for acne prone skin; dedicated to imperfect and damaged skins, to improve the skin perfection, reduces skin blemishes helps to develop a more uniform and velvety complexion
  • Restores well-being to the scalp thanks to its anti-inflammatory activity and strengthens the hair by acting on the dermopapilla.

mechanism of action

The production of fatty acids characterized by a significant increase of IL-1 and occur during the development of acne. Lipid peroxide augmentation would be the one responsible for the progression of inflammatory changes from comedones, promote the production of proinflammatory cytokines and activate peroxisome proliferator activated receptors (PPARs), nuclear hormone receptors which play essential regulatory role in lipid metabolism and inflammation. Verbascoside could use the same pathway as PPAR-α agonists in inflammatory diseases.

in vitro testing

  • Cellular vitality on hair follicles dermopapilla

in vivo testing

  • Sebum regulating activity
  • Reduction of acne severity
  • Increase of skin hydration
  • Reduction of trans epidermal water loss (TEWL)

Reduction of acne severity

  • 20 subjects (Caucasian women and men, 18-55 years old) with acne disease grade I and II
  • Twice a day treatment of 8 weeks day with face cream containing ForsINgen CROP®-G.
  • The inflammatory (papules and pustoles) and non-inflammatory lesions (comedones) was counted in the facial area and a score between 1 and 3 was awarded.

After 8 weeks of treatment with a cream with ForsINgen CROP®-G there is a significant reduction of inflammatory lesions, non-inflammatory lesions and of the severity of acne. The treatment was carried out during the period of restrictions for Covid-19, The subjects wore the surgical masks, known to accentuate epidermal stress.

product specification

The Mother Plant of Forsythia suspensa, capable of generating specific substances useful for its growth and development within an ideal phytocomplex, is carefully selected and certified by DNA fingerprint technique.

Forsythia suspensa, variously called the Chinese golden bell tree, or Green Forsythia is a species of flowering plant in the genus Forsythia in the Oleaceae family. In the language of flowers, it indicates fleeting beauty due to an extremely short but very showy flowery. The fruit is antibacterial, antifungal, antispasmidic and emmenagogue. It is traditionally used in Korea to treat various inflammatory conditions.

INCI Glycerin, Forsythia Suspensa Callus Lysate
Active compounds Total polyphenols expressed as verbascoside equivalent ≥ 0,16% W/W by UPLC-DAD
Appearance Light brown liquid, characteristic odour
Concentration use Starting at 0,15% W/W

lymph science: acne vulgaris, an inflammatory disease

Acne vulgaris is a common chronic inflammatory disease often characterized by elevated sebum production related to androgen stimulation of sebaceous glands, altered keratinization, Propionibacterium acnes, colonization or other bacterial infection, innate imunity activation, and inflammation.  Key inflammatory mediators produced in acne-prone skin can be detected before the development of clinical lesions and even in the absence of P. acnes.

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