MeliBrainTech-PC

MeliBrainTech-PC is a standardized phytocomplex derived from controlled cultures of Melissa officinalis titrated in total polyphenols expressed as rosmarinic acid equivalents.

ITALIAN PATENT N. 102019000004113 INTERNATIONAL PATENT APPLICATION PCT/IB2020/052589

• Anti-inflammatory activity (iNOS, COX2, IkB-α, TNF-α, IL1-β)
• Antioxidant activity (ROS inhibition, protection of mitochondrial morphology)
• Protective activity of dopaminergic neurons in Parkinson’s related disorders
• Neuroprotective activity

Cell viability of BV-2 immortalized murine microglial cells was assessed after stimulation using LPS 250 mg/ml for 24 hours was used to evaluate the neuroprotective effect of MeliBrainTech-PC on the neuronal line SH-SY5Y in comparison with two commercially available dry extracts of Melissa officinalis, at a concentration of 10µg / ml. After 24 hours from the inflammatory stimulus with LPS, protection from neurotoxicity was assessed. MeliBrainTech-PC showed a greater disposition to prevent neurotoxicity than the two extracts on the market and statistically significant protection from neuroinflammation.

The Mother Plant of Melissa officinalis, able to generate specific substances useful for its growth and development within an ideal phytocomplex, has been carefully selected and certified through the DNA fingerprinting technique. Melissa officinalis, also known as lemon balm, has a traditional medical application centered on the plant’s essential oil components and rosmarinic acid for its relaxing properties. Studies have shown that traditional relaxation effects may be associated with elevated levels of the neurotransmitter GABA (γ-aminobutyric acid) by inhibiting GABA-transaminase (GABA T), an enzyme that degrades GABA. In addition, rosmarinic acid is able to inhibit the enzyme acetylcholinesterase, which degrades the neurotransmitter acetylcholine, related to Alzheimer’s disease.